Primary entity: 5-Amino-1MQClass: NNMT inhibitor — not a peptideCluster: Specialty / metabolic adjacent
5-Amino-1MQ is a cell-permeable small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) — not a peptide. It appears in research-chemical and “peptide shop” marketing because of metabolic / body-composition folklore. Published efficacy evidence remains preclinical (cell/rodent) in the public record cited here; it is not FDA-approved.
5-Amino-1MQ is not a peptide. It is a methylquinolinium small molecule. Shops shelve it next to peptides for marketing adjacency only.
Not FDA-approved. FDA has publicly treated related compounding/503B eligibility negatively in enforcement-adjacent materials for this substance class/name. No established ClinicalTrials.gov exact-name human program located in secondary literacy sources cited here. Gray-market capsules/powders ≠ clinical supply.
Key takeaways
- Not a peptide — NNMT-inhibitor small molecule.
- Not FDA-approved; human trial record not established in the sources cited here.
- Evidence center of gravity: cell + rodent metabolic models.
- No dosage / “fat-loss capsule” charts.
Questions this page answers
Next questions we answer on this page (curiosity / AI-gap map):
- What is 5-Amino-1MQ?
- Also known as
- Classification
- What it is NOT
- Mechanism (NNMT)
- Evidence ladder
- What’s been studied
- Safety literacy
- Regulatory status
- Why no dosages
- Related compounds
- Who for / not for
Who is this profile for — and who is it not for?
For: readers correcting “peptide” miscategorization and needing preclinical-vs-hype literacy.
Not for: anyone seeking buy links, oral fat-loss protocols, or medical advice.
What is 5-Amino-1MQ?
5-Amino-1MQ inhibits NNMT, an enzyme that methylates nicotinamide and influences NAD+-related metabolic networks in research models. That biochemistry explains obesity/sarcopenia-adjacent mouse papers — not consumer approval.
Related non-peptides: BAM15, Cardarine.
| Chemistry | NNMT inhibitor (methylquinolinium) |
|---|---|
| Peptide? | No |
| U.S. approval | Not approved |
| Human RCTs | Not established in draft sources |
| Evidence | Cell + rodent |
Also known as
- 5-Amino-1MQ / 5-amino-1-methylquinolinium
- 5amino1mq — search compression
- Mis-tags: “5-Amino-1MQ peptide” — category error
Wrong chemistry class. Even as a research small molecule, human outcome evidence is not established here.
How is 5-Amino-1MQ classified?
Investigational research small molecule filed under specialty/metabolic adjacency because SERP demand clusters with peptides. Explicit not-a-peptide ship gate.
What is 5-Amino-1MQ not?
| 5-Amino-1MQ is not… | Why that matters |
|---|---|
| A peptide | Small molecule |
| FDA-approved weight-loss drug | No approval |
| Human-proven NNMT therapy | Preclinical center of gravity |
| Something we dose or source | Refusal |
How is 5-Amino-1MQ thought to work?
NNMT inhibition in cells/animals is linked to altered nicotinamide / NAD+ metabolic flux and downstream energy-expenditure / adipose phenotypes in models. Mechanism in mice ≠ labeled human drug.
What human vs animal vs label evidence exists?
| Evidence type | What exists (summary) | Maturity |
|---|---|---|
| Cell / enzymology | NNMT inhibition studies | Cell |
| Animal | Diet-induced obesity / muscle aging models | Animal |
| Human interventional | Not established in draft scan | None |
| Approved label | None | None |
What has been studied?
Preclinical themes: obesity, glucose handling, liver pathology markers, and aged-muscle function in rodents. Studied in mice ≠ approved for people.
What safety topics come up?
No approved human safety database like a labeled drug. Unregulated oral products add identity/purity risk. Not medical advice.
What is 5-Amino-1MQ's regulatory status?
- U.S.: Not FDA-approved. Compounding eligibility has is not an FDA-approved drug, and this page does not treat a specific unpublished warning letter as confirmed.
- Trials: Check ClinicalTrials.gov for any current exact-name studies.
Why doesn't this page include a dosage chart?
Preclinical-only efficacy story + unapproved status. No “mg fat loss” charts.
Related lab literacy
Not a peptide reconstitution topic. See What are peptides? for class literacy.
Related compounds and comparisons
- AOD-9604 — GH fragment peptide with failed obesity Phase IIb narrative.
- BAM15 — mitochondrial uncoupler (also not a peptide).
- MOTS-c — mitochondrial peptide (different class).
- Cardarine — another non-peptide metabolic folklore agent.
Frequently asked questions
Is 5-Amino-1MQ a peptide?
No. It is a small-molecule NNMT inhibitor.
Is 5-Amino-1MQ FDA approved?
No.
Are there human trials?
Exact-name human interventional evidence was not established in sources cited here.
Why do peptide shops sell it?
Marketing adjacency to metabolic peptides — not chemistry identity.
Why no dosage chart?
YMYL + preclinical-only story.
Not a peptide and not FDA-approved. Disclaimer.
Sources
The sources below were checked against PubMed, DailyMed, or the official agency page on November 10, 2026 (America/Phoenix). Links go to the publisher, PubMed, or the agency record.
- Primary — animal PK Awosemo O, Neelakantan H, Watowich S, et al. Development & validation of LC-MS/MS assay for 5-amino-1-methyl quinolinium in rat plasma: Application to pharmacokinetic and oral bioavailability studies. J Pharm Biomed Anal. 2021. doi:10.1016/j.jpba.2021.114255. PMID: 34304009. Identifies 5-AMQ as an NNMT inhibitor and reports rat pharmacokinetics only.
- Regulatory literacy U.S. Food and Drug Administration. FDA 101: Dietary Supplements. Accessed November 10, 2026. 5-Amino-1MQ is not an FDA-approved drug. This page does not treat a specific unpublished warning letter as confirmed.
- Written by
- Peptide Tutorials Staff — a group of independent researchers & writers (not clinicians)
- Published · Updated
- Oct 6, 2026 · Oct 6, 2026 · Regulatory and sport-status wording checked November 10, 2026 against current FDA labels and the 2026 WADA Prohibited List · How we source & update
Educational disclaimer: Educational only. 5-Amino-1MQ is not a peptide. No dosing or buy links. We don’t sell peptides. Read our full disclaimers.